
The Final Frontier of Drug Delivery: Navigating the Blood-Brain Barrier
The next generation of CNS therapies will depend on crossing the blood-brain barrier safely, selectively, and at therapeutic scale.


Robert S. Langer is a chemical engineer and MIT professor known for his groundbreaking work in biotechnology, nanotechnology, and regenerative medicine. As a co-founder of Moderna, his research has played a central role in developing cutting-edge technologies such as mRNA therapeutics, controlled drug delivery, and tissue engineering.
Langer envisioned therapeutic uses for mRNA beyond the COVID-19 pandemic. In his lab, he developed nanoparticle systems using polymers and lipids to safely deliver mRNA, enabling next-gen vaccines and treatments for cancer, respiratory viruses, and rare diseases.Today, mRNA technology is used against RSV and is in clinical trials for norovirus, flu, cystic fibrosis, and cancer.
His lab pioneered the use of biocompatible and biodegradable polymers that allow for targeted and time-controlled drug delivery. These systems reduce toxicity and are capable of transporting proteins, genes, and chemotherapy agents to specific locations such as tumors or even the brain.
Langer’s team is developing polymer scaffolds and nanofiber systems to grow functional tissues—like skin, blood vessels, and even organs-on-chips. They also explore 3D printing and AI to accelerate the discovery and design of new biomaterials.
Langer points to financial and regulatory hurdles in biomedicine. While safety protocols are vital, he believes smart risk-benefit strategies are essential for progress. He highlights Operation Warp Speed as a model for public-private collaboration.He also emphasizes global equity in access to healthcare, supporting partnerships with the Gates Foundation to bring vaccines and therapies to low-income regions.
With over 1,600 scientific articles and 1,400 patents, Langer is one of the most prolific inventors in history. His accolades include:
Langer blends science, engineering, and entrepreneurship to transform modern medicine. His breakthroughs in mRNA, nanomedicine, and tissue scaffolding are reshaping personalized healthcare and drug delivery. He continues to challenge limits in science and policy to democratize life-saving technologies.

The next generation of CNS therapies will depend on crossing the blood-brain barrier safely, selectively, and at therapeutic scale.

Even the strongest science does not guarantee an investable asset. Here, we discuss how to align early-stage discovery programs for small molecules with investor expectations in a complex biotech funding environment.
Join us in building the future of medicine through innovative technology and biology convergence